Explore Careers

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated, scientific leader with a deep knowledge of cancer biology and lineage transcription factors, and a demonstrated track record of success in target validation and small molecule drug discovery to join our team in South San Francisco. The successful candidate will enact a leadership role on a multi-disciplinary project team to drive small molecule drug discovery from inception into the clinic. He/she will define the path to drug discovery from target validation through to candidate selection by leveraging internal and external resources. The candidate will be expected to develop strong, collaborative partnerships within the company, with external collaborators, and with CROs.

KEY RESPONSIBILITIES

• Conceive, communicate and execute on multi-disciplinary research strategies for elucidating the mechanistic basis of target dependency to inform targeting modality, and for identifying biomarkers for early patient stratification.
• Co-lead the new target hit identification team to advance new programs to hit-to-lead stage and beyond.
• Closely collaborate with the medicinal chemistry co-lead in the prioritization of new targets entering hit finding, the design and execution of appropriate screening strategies, the validation and triage of screening hits, and the initial SAR exploration around these hits.
• Coordinate research activities and effectively allocate resources between internal staff, external CROs and other external collaborators.
• Keep up to date with the latest scientific advances in technologies and trends in oncology research and development to deliver the next generation of oncology discovery therapies.
• Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. with a focus on cancer biology, developmental biology, or a closely related area of study.
• 8+ years of hands on small molecule drug discovery experience in the oncology therapeutic area in an industry setting.
• Demonstrated success working with external partners.
• Prior experience in transcription factor drug discovery highly desired.
• A strong record of achievement, including publications in high-impact journals and advancing targets into the drug discovery portfolio.
• Leading and mentoring a group of Ph.D. and non-Ph.D. scientists and facilitating their contributions to project teams /research collaborations.
• Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• Outstanding decision making, organizational and analytical skills.
• Excellent interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-EJ1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology, and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

As a Lab Operations Associate, you will work closely with the rest of the Boston site Operations team to support all areas of the business including asset management of lab instrumentation, shipping & receiving, inventory management, vendor management, lab safety and compliance initiatives, and more. This position will play a critical role in implementing and maintaining scalable systems and practices to support the developing culture and daily operations of our rapidly growing R&D teams.

RESPONSIBILITIES

• Work with Lab Operations team to maintain a tidy and efficient lab setting, providing a customer service experience to the R&D teams.
• Maintain an efficient and organized laboratory supply inventory with support from the Lab Ops and Facilities associates.
• Assist with domestic and international shipping needs between Scorpion sites and/or external parties.
• Collaborate with Procurement and Finance groups to achieve a controlled, compliant ordering process for R&D services and supplies.
• Assist with lab equipment management, maintenance schedules, and troubleshooting.
• Assist with oversight of equipment monitoring services and participate in responding to any alarms as needed.
• Coordinate with third party EH&S services to maintain a safe and compliant lab space.
• Communicate regularly with lab employees and research teams to assess overall lab function and identify any unmet needs or deficiencies.

QUALIFICATIONS

• Associate or bachelor’s degree in a related field of study.
• 1+ years related Life Sciences work experience in a biological lab setting, with emphasis on lab and facilities, required.
• Proficient knowledge of laboratory equipment and procedures, safety regulations, and chemical hygiene, required.
• Previous lab safety training/experience, required.
• High attention to detail, including a proven ability to manage multiple, competing priorities simultaneously, as well as the ability to think strategically and execute methodically.
• Working knowledge of Microsoft Office Suites.
• Excellent communication skills, verbal and written.
• Ability to work effectively in a fast-paced environment.
• Must be able to lift up to 40lbs.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-RC1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking an experienced Paralegal to join our team at Scorpion Therapeutics in Boston, MA. This is an opportunity to be one of the early members of Scorpion Therapeutics Legal Team. You will be responsible for providing administrative and project support to attorneys and other members of the team. This position will be responsible for handling a wide variety of duties, which include, but are not limited to, those listed below. If you enjoy working in a fast-paced and rapidly growing environment, this could be the opportunity for you!

RESPONSIBILITIES

• Be responsible for promptly reviewing, handling and triaging all legal correspondence.
• Assist with tracking and maintaining corporate compliance records.
• Assist with scheduling and coordinating meetings, trainings and other team activities.
• Assist with maintaining corporate entity organizational and governance documents, including state filings and annual reports.
• Develop process and procedures in managing and tracking legal and corporate governance documents.
• Assist with template development, drafting and preparing forms, letters and other legal documents and coordination of approvals, signatures and notarization of documents.
• Assist with internal audits, metrics generation, and maintenance of contract management system.
• Support the legal team with budget management and billing.
• Update template agreements and assist with contract review.
• Assist General Counsel with researching, responding to, and resolving ethical and policy issues.
• Perform any and all other duties as necessary for the efficient functioning of the office.

QUALIFICATIONS

• Bachelor’s degree and a minimum of 5 years of experience as a paralegal.
• Experience providing paralegal-level support in a life sciences environment a plus.
• Legal operations experience, including implementing contract management tools.
• Project management skills, including the ability to establish the project scope, establish a timeline, manage resources and prioritize and meet deadlines.
• You have a strong commitment to personal and professional ethics and integrity.
• You have excellent written and oral communication skills with strong attention to detail.
• You are resourceful and able to seamlessly multi-task various matters.
• Paralegal certificate is encouraged but not required.
• Notary public or willingness to become one upon joining.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-AF1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

As the Principal People & Culture Partner, you will be a trusted advisor and business partner to the company’s senior leaders, functioning as the expert on people and organizational issues and providing guidance on managing complex and sometimes sensitive employee relations matters. You will contribute to driving critical results during an exciting time of business transformation. This role will be instrumental in shaping our culture, supporting our business strategies and developing the talent pipeline necessary to make a significant impact on Scorpion Therapeutics’ ability to develop the next generation of cancer therapeutics. You will utilize HR best practices to lead, develop, deliver and support programs that establish Scorpion Therapeutics as a top desired employer.

KEY RESPONSIBILITIES

• Build upon the existing People function and create a “best practices” People & Culture organization.
• Lead Strategic Workforce Planning that includes identifying people and organizational implications of the business strategy, identifying key talent and driving accelerated development and succession plans.
• Plan, develop and implement initiatives and programs in leadership & employee development, compensation, benefits, training and development to ensure client’s needs are understood and met by corporate- wide programs.
• Provide counsel to the Scorpion Leadership Teams on the full scope of people practices. Be able to engage in meaningful discussions about the R&D, financial and operational aspects of the business.
• A trusted advisor/thoughtful sounding board and business partner to the company’s senior leaders, functioning as the expert on people and organizational issues and providing guidance on managing complex and sometimes sensitive employee relations matters.
• Drive and support an open and inclusive culture that embraces individual difference.
• Operate as a strategic partner to the business, developing People strategies, needs assessments and resulting People solutions.
• Partner with leaders to model and foster an environment where every employee is engaged and inspired to contribute their best.
• Ensure the effective delivery of all People programs and practices.
• Assist with the design and delivery of programs and initiatives to attract, retain and promote a diverse and inclusive workforce.
• Coach senior leaders on complex leadership and People issues including development, engagement, and talent performance.
• Ensure alignment with culture and strategic initiatives across their multi-location employee organization.
• Partner with the leaders and employees to foster a unified culture that inspires excellent performance and strong employee engagement.
• Establish, build and maintain positive relationships with key stakeholders.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Bachelor’s degree required; advanced degree preferred.
• 10-12 years of progressive experience in all aspects of People Practices, Culture and Employee Experience.
• Experience developing and implementing People & Culture strategies with broad, corporate-wide impact.
• Ability to develop positive, professional relationships with senior leadership, employees and peers in a fast-moving start-up environment.
• Experience developing strategic workforce plans, from conception to implementation.
• Expertise in talent management, succession planning, and career growth and development.
• Knowledge of HR regulations and standards affecting the business.
• Understanding of and significant expertise with organizational effectiveness, leadership development, employee relations, data and analytics and diversity and inclusion.
• Skilled at data analytics and ability to navigate multiple data sources and metrics to create and drive aligned business solutions.
• Highly skilled at building strong, credible partnerships with senior leaders, people managers and employees across the organization.
• Exceptional interpersonal, verbal/written communication skills, and attention to detail.
• Able to work independently, take initiative, maintain relationships and be able to work effectively and collaboratively with all levels within the organization.
• Capable of leading and managing across a wide variety of business areas.
• Ability to maintain strict confidentiality, act with a high level of tact, diplomacy, discretion and emotional intelligence.
• Strong project management skills with ability to execute on short- and long-term deliverables.
• Executive presence; experience in facilitation and presentation with key partners and leaders.
• A strategic problem solver, who uses data and analytics to inform decision making and leadership coaching.
• High business acumen and deep industry knowledge.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-AV1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

You’ll deploy in silico techniques to design small molecule therapeutics and you’ll partner with the medicinal chemistry lead to develop hit-to-lead and lead optimization strategies. You’re an integral member of cross-functional project teams to discover quality development candidates by helping define issues, design (virtual) screening and optimization strategies, and drive insights from the integration of experimental, structural, and in silico data. In addition, you’ll identify and incorporate novel approaches in collaboration with the data science team to further enhance our molecular design platform.

KEY RESPONSIBILITIES

• Collaborate with cross-functional project teams to design novel therapeutics using structure-based and ligand-based approaches like free energy perturbation, molecular dynamics, QSAR, machine learning and others.
• Develop hit-to-lead and lead optimization strategies in partnership with the chemistry project lead.
• Design molecules towards optimal ADME and physicochemical properties, in addition to potency and selectivity, in collaboration with the medicinal chemistry team.
• Contribute to the development of our computational infrastructure by identification and incorporation of novel tools and techniques in collaboration with the data science and broader Scorpion team.
• Collaborate with the data science and chemistry team to help integrate data analytics approaches into all aspects of drug discovery.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Passionate drug hunter.
• PhD with 6+ years or BS/MS with 12+ years of computational chemistry support in a pharmaceutical and/or biotechnology environment.
• Demonstrated contributions to the advancement of drug discovery programs through the application of computational chemistry techniques.
• Proficiency with a broad range of computational chemistry techniques, including docking and scoring, molecular dynamics, (cryptic) pocket identification and characterization, FEP, homology modeling, quantum mechanics, QSAR and pharmacophore modeling.
• Extensive experience with data analytics approaches (clustering, matched pair analysis, activity cliff analysis, MPO approaches, data visualization) and tools (e.g. KNIME, Jupyter notebook, PipelinePilot).
• Experience with chemistry toolkits (e.g. RDKit, ChemAxon, DeepChem).
• Experience with covalent drug discovery a plus.
• Experience with full Schrödinger software suite a plus.
• You are a great communicator who enjoys working in a highly integrated, fast-moving biotech environment.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-NB1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

This is an exciting opportunity to be part of an evolving Talent Acquisition Team at Scorpion Therapeutics and to be a trusted and visible talent advisor to hiring managers across the company. We are looking for a talented individual who is creative, passionate, and proactive about talent acquisition and excited to contribute to the development of novel small molecule therapeutics to fight cancer. In this role, you will report to the Chief People Officer and partner with People & Culture colleagues, hiring managers, and business leaders to develop and deliver effective recruiting strategies to hire top talent. You will manage the full lifecycle recruiting process from the recruitment strategy though offer negotiation, driving the hiring process at Scorpion Therapeutics to meet its near and longer-term strategic hiring objectives.

KEY RESPONSIBILITIES

• Partner with hiring managers and leaders across the organization to define roles, measure and communicate progress, improve existing programs and develop innovative sourcing and recruiting strategies.
• Act as a trusted advisor to managers and leaders by proactively gathering market insights and intelligence related to talent and the competitive biopharmaceutical talent landscape.
• Ensure consistent and effective communication approaches with regard to recruiting efforts by providing status updates to all stakeholders through meetings, email updates, weekly, monthly, and quarterly updates.
• Provide effective recruitment solutions by providing input on job descriptions, developing strategic sourcing stratagies for key positions, effectively managing all available Talent Acquisition tools and resources, performing outbound recruiting and sourcing, reviewing resumes, conducting interviews and creating and negotiating offers.
• Source top Life Sciences/Biotech talent across several disciplines through multiple channels and build healthy robust pipelines of highest quality candidates on a continuous basis from which we can effectively hire and grow the team.
• Review resumes and interview candidates to determine the appropriateness of skills, experience, and knowledge in relation to position requirements across all different disciplines and all levels.
• Collaborate with the Chief People Officer to develop and execute functional talent strategies ensuring workforce diversity, integrated talent management and talent pipelining ensuring critical hard to fill needs met.
• Help to define effective, simple, and compliant recruiting processes while building strong partnerships with hiring managers and teams.
• Develop robust talent management plans and drive culture change initiatives to attract, retain, develop, and engage talent in critical roles.
• Follow industry trends, and leverage insights to develop effective strategies and solutions.
• Introduce new and/or improved methodologies for attracting, assessing, and selecting the best talent.
• Identify future talent needs and develop appropriate talent pools.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• B.S./B.A. degree required; advanced degree highly desirable.
• 8-10+ years of successful full lifecycle recruiting experience in Life Sciences/Pharma/Biotech industry (or equivalent transferrable experience).
• Experience in full lifecycle recruiting, including sourcing, screening, negotiations, closing, and candidate relationship management.
• Provide excellent support and effective communication all along the recruitment to ensure an excellent candidate and hiring manager experience.
• Ability to build strong, productive relationships with hiring managers, leaders and external vendors.
• Experience managing and prioritizing multiple searches, projects, and client relationships and succeeding in a fast-paced dynamic environment.
• Proficient use of Microsoft Suite products, Applicant Tracking Systems, and LinkedIn.
• Effective judge of talent; proven ability to assess talent and ability to articulate candidates’ strengths and limitations, values and motivators.
• Demonstrated experience with all aspects of the sourcing and recruiting process, with the willingness/capability to be both hands-on and consultative.
• Ability to effectively manage external search partners as needed; manage vendor relationships and performance.
• Team player with a “hands on” approach willing to roll-up your sleeves and get the job done.
• Exceptional organizational skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-AV1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

All projects at Scorpion are run by project teams and project team leaders are directly accountable for the success of our drug-discovery programs and the value creation they enable. Project Team Leaders are given significant autonomy and resources to prosecute projects rapidly, efficiently, and at the highest scientific and industry standards. Given their importance to our company and this operating model, project team leaders are directly accountable to and report to senior management.

We are seeking a highly motivated, experienced research Project Leader with a demonstrated track record of success in leading oncology small molecule projects from discovery into early clinical testing. He/she will be accountable for setting project strategy and leading project execution with the goal of advancing clinical candidates with compelling data packages in line with our overall corporate goals.

The successful candidate, along with a chemistry colleague, will lead a multi-disciplinary project team to drive oncology small molecule drug discovery from inception into the clinic. He/she will define the path to drug discovery from target validation to candidate selection through leveraging internal and external resources. The candidate must have demonstrated experience in all aspects of identifying, characterizing and advancing high-quality drug candidates into first-in-man clinical trials, including defining biomarker strategy, patient stratification, and proof-of-mechanism endpoints. The candidate will be expected to develop strong, collaborative partnerships within the company, with academic investigators associated with the company, and with CROs.

KEY RESPONSIBILITIES

• Directly lead small-molecule drug discovery programs.
• Design and implement project strategies leading to the identification of high-quality development drug candidates.
• Identify key decision points and manage risk and expectations to meet short and long-term objectives successfully.
• Coordinate research activities and effectively allocate resources between internal staff and external CROs.
• Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. degree in biochemistry, (cancer) biology, pharmacology, or related discipline.
• 10 years of hands-on small molecule drug discovery experience in the oncology therapeutic area in an industrial setting.
• Demonstrable hands-on experience in all aspects of advancing small molecule drugs through lead optimization to candidate selection, with broad knowledge across multiple disciplines including pharmacology, pharmacokinetics, medicinal chemistry, ADME and toxicology.
• Demonstrated leadership of multidisciplinary project teams through all stages of small molecule discovery including candidate selection with the ability to define strategy and provide leadership.
• Deep understanding of small molecule drug discovery – instinctive identification of critical success factors, anticipation of issues before they occur and mitigation of risk while driving a program forward.
• A deep and broad understanding of cancer biology, including preclinical and translational aspects.
• Demonstrated ability to lead, organize and manage productive, cross-functional and cross-site teams.
• Exceptional scientific rigor coupled with experience in high-level decision making.
• The desire and ability help lead teams working on challenging scientific problems and first-in-class therapeutics.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy, and a collaborative spirit.
• Outstanding oral and written communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-DS1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated research associate to join our dynamic drug discovery team. This candidate will serve a critical role in establishing and running in vitro bioassays to help drive our small molecule drug discovery programs. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Developing robust biochemical assays for compound profiling, high-throughput screening, and mechanistic studies.
• Providing small molecule inhibition data throughout different stages of drug discovery programs.
• Designing and executing experiments to study the mechanism of inhibition of small molecule inhibitors in biochemical and/or cell-based assays.
• Drafting assay protocols/SOPs.
• Managing internal and external assay data, recording experiments and uploading data into electronic lab notebook.
• Using decision making, organizational and communication skills to effectively collaborate with colleagues in biology, chemical biology, and medicinal chemistry.
• Presenting data and findings at various venues, including project team, department, and company meetings.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• BS/MS in Biochemistry, Biology or a related field, with 1-3 years experience (Research Associate) or more than 5 years experience (Sr. Research Associate) supporting drug discovery projects.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A deep and broad understanding of assay development, automation systems, and compound management in drug discovery.
• Experience in biochemical assays with a variety of detection methods in 96 and 384-well plates.
• Experience with mammalian cell culture and cell-based assays is a plus.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• The desire and ability to contribute to teams working on challenging scientific problems and first-in-class therapeutics.
• A strong record of achievement, including contributing to drug discovery programs and publications is highly desirable.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-WW1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated research associate to join our dynamic biology drug discovery team. This candidate will serve a critical role in establishing and running cell-based assays to inform target biology and help drive our small molecule drug discovery programs. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Designing and executing experiments to inform target biology using a variety of approaches, including cell line engineering, analysis of signaling pathways, and characterization of cell death mechanism(s).
• Developing and executing high throughput cell-based assays.
• Designing and conducting mechanism of action studies on small molecule inhibitors.
• Developing in vitro and in vivo pharmacodynamic readouts for novel oncology targets.
• Genetic manipulation of cells utilizing knockdown or knockout and over-expression of proteins for target validation.
• Using decision making, organizational and communication skills to effectively collaborate with colleagues in biology, chemo-proteomics, and medicinal chemistry.
• Documenting and presenting data, findings, and experimental conclusions at various venues, including project team, department, and company meetings.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• BS/MS in Biology or a related field, with oncology experience preferred but not required.
• 1-3 years of relevant laboratory experience.
• A deep and broad understanding of cell culture, assay implementation, and data processing with excellent scientific rigor.
• Prior experience with cell line genetic manipulation (e.g. CRISPR) is a plus.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• The desire and ability to contribute to teams working on challenging scientific problems and first-in-class therapeutics.
• A strong record of achievement, including contributing to drug discovery programs and publications is highly desirable.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-MM1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated research associate to join our dynamic biology drug discovery team in South San Francisco. This candidate will serve a critical role in establishing and running cell-based assays to inform target biology and help drive our small molecule drug discovery programs. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Designing and excuting experiments to inform target biology using a variety of approaches, including cell line engineering, analysis of signaling pathways, and characterization of cell death mechanism(s).
• Developing and executing cell-based assays with genetically manipulated cells and small molecule inhibitors.
• Designing and conducting mechanism of action studies on small molecule inhibitors.
• Developing pharmacodynamic readouts for novel oncology targets.
• Utilizing knockdown or knockout and over-expression of proteins for target validation.
• Using decision making, organizational and communication skills to effectively collaborate with colleagues in biology, chemo-proteomics, and medicinal chemistry.
• Presenting data and findings at various venues, including project team, department, and company meetings.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• BS/MS in Biology or a related field.
• 1-3 years of relevant laboratory experience.
• A deep and broad understanding of cell culture, assay implementation, and data processing with excellent scientific rigor.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• The desire and ability to contribute to teams working on challenging scientific problems and first-in-class therapeutics.
• A strong record of achievement, including contributing to drug discovery programs and publications is highly desirable.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-GC1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D.and Liron Bar-Peled, Ph.D. Scorpion has secured $270 million in financing since it was founded in the first quarter of 2020 with Series A and B rounds led by Atlas Venture, Omega Funds, Vida Venture, with participation by Abingworth, Partners Health Care, and others.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly driven Scientist with a deep understanding of biochemistry and assay technologies to join our dynamic drug discovery team in South San Francisco. The successful candidate will be a proven expert in the design, development and execution of biochemical activity and binding assays. This role will contribute to the growth of Scorpion’s research portfolio by developing assay strategies to advance the discovery of novel precision oncology therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Contribute to the ideation of hit finding strategies, and design and develop robust biochemical/biophysical assays for compound profiling to drive drug discovery efforts and establish SAR.
• Collaborate effectively with cross-functional partners within Scorpion to define and develop screening cascades for Scorpion’s novel targets.
• Profile compounds for potency, selectivity and MOA.
• Translate proof-of-concept assays into high-quality, miniaturized assays that have been optimized & validated to meet predefined standards of performance.
• QC and analyze data & document all findings & discoveries in an electronic lab notebook in a timely manner.
• Work collaboratively with colleagues in new target biology, chemical biology, informatics, structural biology and medicinal chemistry to advance programs from early hit-finding and help prioritize projects for advancement into lead optimization.
• Proactively communicate strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external colleagues.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in Biochemistry, Biophysics or a related field with 3+ years of industry experience or a MS in Biochemistry, Biophysics or a related field with 7+ years of industry experience.
• Demonstrated hands-on expertise in developing, trouble shooting, and running biophysical, biochemical, and enzyme assays such as HTRF, TR-FRET, FP, DSF, AlphaLISA, etc.
• Expertise in handling, analyzing and visualizing large data sets coming out of screening assays.
• A strong record of achievement, including contributing to drug discovery programs and publications in high-impact journals.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged self-starter with the desire to work in a fast-paced, multi-tasking environment, with both a collaborative and goal/results-orientated style.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-SP1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated Computational Biologist to join our Data Science team. This role will provide exposure to multiple phases of drug discovery and development, with a mission to leverage information-rich datasets to validate targets, elucidate mechanism of action, and inform patient selection strategy. The successful candidate will interact closely with colleagues across the company, and be a key contributor on a diverse, multidisciplinary team.

KEY RESPONSIBILITIES

• Identify and evaluate novel therapeutic targets through mining large omics datasets.
• Analyze data from high-throughput molecular assays including RNA-seq, ChIP-seq, ATAC-seq and CRISPR screens.
• Work in close collaboration with scientists from target identification and validation group contributing to experimental design.
• Provide analysis and interpretation of results and present findings in cross-functional project team meetings.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in Computational Biology, Bioinformatics, Statistics, or other quantitative field.
• Strong coding skills, fluency in R or Python for complex data analysis and visualization.
• Experience in analysis of large datasets from high-throughput sequencing (e.g. RNA-, DNA-, ChIP-, and ATAC-seq).
• Strong understanding of relevant concepts in cancer biology and molecular biology.
• Understanding of current best practices for high-throughput genomics/molecular data analyses and their underlying statistical principles.
• Experience in network/pathway mapping and integration of orthogonal omics datasets.
• Experience with AWS compute environment is highly preferred.
• Experience with Nextflow DSL is a plus.
• Experience with R-Shiny is a plus.
• A strong record of achievement, including publications in high-impact journals.
• Integrity, scientific rigor and commitment to teamwork.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-PJ1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D.and Liron Bar-Peled, Ph.D. Scorpion has secured $270 million in financing since it was founded in the first quarter of 2020 with Series A and B rounds led by Atlas Venture, Omega Funds, Vida Venture, with participation by Abingworth, Partners Health Care, and others.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

Many transcription factors have long been appreciated as important cancer drivers and targets for novel therapies, but have historically been considered “undruggable” using conventional drug discovery approaches. Scorpion Therapeutics is utilizing our fully integrated discovery platform to overcome the challenges of targeting transcription factors.

We are seeking a highly motivated cancer biologist to join our Target Biology team in South San Francisco. The successful candidate will have an in depth knowledge of transcription factor function including mechanisms of regulation, interaction with transcriptional mahinery and dynamics of DNA binding. They will play a key role in driving early drug discovery efforts by utilizing cutting edge functional genomic techinques and developing and implementing a variety of biochemical and cell based methods to elucidate target function and enable small molecule screening efforts.

KEY RESPONSIBILITIES

• Design and execute a series of experiments to drive in depth target characterization and elucidate mechanisms of transcription factor regulation using genetic and pharmacological perturbation.
• Design, develop, and implement robust biochemical- and cell-based assays to characterize drug/target MOA and measure compound potency and selectivity.
• Collect, process, analyze, and summarize data for presentations, reports, publications, and patents.
• Keep up to date with the latest scientific advances in technologies and trends in oncology research and development, and contribute to group strategy.
• Mentor and direct junior lab members.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. with a focus on cancer biology, cell or molecular biology, genetics or a closely related area of study.
• 2+ years of experience in small molecule drug discovery and a deep knowledge of cancer biology.
• Hands-on experience with cell-based, biochemical and biophysical assay techniques typically used to study transcription factor activity and binding interactions.
• Expertise in genetic perturbation (CRISPR and RNAi) and genetic rescue techniques.
• A strong record of achievement, including publications in high-impact journals.
• Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• Outstanding decision making, organizational and analytical skills.
• Excellent interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-EJ1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

This is a unique opportunity to join an early-stage biotechnology company that combines world-class genomics, chemical proteomics, and data science capabilities and contribute to bringing drugs towards the clinic. We are a highly integrated drug discovery company and are looking for a results-oriented team player who enthusiastically integrates computational chemistry, computational biophysics, structural informatics and cheminformatics approaches to help drive Scorpion Therapeutics’ drug discovery programs.

KEY RESPONSIBILITIES

• Provide integrated computational chemistry support to enable efficient lead discovery and optimization.
• Utilize ligand- and receptor-based screening approaches to identify starting points for novel targets.
• Integrate novel computational biophysics approaches like molecular dynamics and free energy perturbation.
• Contribute to the development of our computational infrastructure by identification of novel tools and techniques.
• Collaborate within the Data Science team to help integrate data analytics approaches into all aspects of drug discovery.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Passionate drug hunter.
• PhD with 6+ years of computational chemistry support in a pharmaceutical and/or biotechnology environment.
• Demonstrated contributions to drug discovery programs through the application of computational chemistry techniques.
• Proficiency with a broad range of modern computational chemistry techniques.
• Experience with full Schrödinger software suite a plus.
• You are a great communicator who enjoys working in a highly integrated, fast-moving cross-functional environment.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-NB1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D.and Liron Bar-Peled, Ph.D. Scorpion has secured $270 million in financing since it was founded in the first quarter of 2020 with Series A and B rounds led by Atlas Venture, Omega Funds, Vida Venture, with participation by Abingworth, Partners Health Care, and others.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly driven Scientist to join our dynamic drug discovery team in South San Francisco. The successful candidate will be a proven expert in the design, development and execution of cellular activity, target engagement and PD mode of inhibition assays. This role will contribute to the growth of Scorpion’s research portfolio by developing cellular assay strategies to advance the discovery of novel precision oncology therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Design and optimize biochemical and cell-based assays to profile compounds for potency, selectivity and MOA.
• Translate proof-of-concept assays into robust, microtiter plate-based cellular assays that have been optimized & validated to meet predefined standards of performance.
• QC and analyze data & document all findings & discoveries in an electronic lab notebook in a timely manner.
• Work collaboratively with colleagues in new target biology, chemical biology, informatics, structural biology and medicinal chemistry to advance programs from early hit-finding and help prioritize projects for advancement into lead optimization.
• Collaborate effectively with cross-functional partners within Scorpion to define and develop screening cascades for Scorpion’s novel targets.
• Proactively communicate strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external colleagues.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in Molecular or Cell Biology, Biochemistry or a related field with 3+ years of industry experience or Masters degree with 6+ years industry experience.
• Demonstrated proficiency in standard assay techniques used in drug discovery such as CTG, TR-FRET, NanoBret, ELISA, AlphaLISA, MSD, etc).
• Proficiency in operating multi-modal plate readers (e.g., Envision, Pherastar), liquid handlers (e.g., Multidrop, acoustic dispensers, digital dispensers) & other automated laboratory equipment (e.g., stackers/plate hotels, incubators, etc.).
• Expertise in handling, analyzing and visualizing large data sets coming out of screening assays.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged self-starter with the desire to work in a fast-paced, multi-tasking environment, with both a collaborative and goal/results-orientated style.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-SP1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D.and Liron Bar-Peled, Ph.D. Scorpion has secured $270 million in financing since it was founded in the first quarter of 2020 with Series A and B rounds led by Atlas Venture, Omega Funds, Vida Venture, with participation by Abingworth, Partners Health Care, and others.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly driven Senior Scientist to join our dynamic drug discovery team in South San Francisco. The successful candidate will be a proven expert in the design, development and execution of cellular and biochemical, activity and binding assays. This role will contribute to the growth of Scorpion’s research portfolio by developing assay strategies to advance the discovery of novel precision oncology therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Contributes to the design of in vitro pharmacology strategies in support of drug discovery projects to determine potency and selectivity of small molecules to understand their SAR and mechanism of action.
• Translate proof-of-concept assays into high-quality, microtiter plate-based cellular and biochemical assays that have been optimized & validated to meet predefined standards of performance.
• Develop sensitive robust cell-based and biochemical assays, troubleshooting experimental design, optimization of assay sensitivity.
• Contribute to conversion of assays into miniaturized high-throughput (HTS) format.
• May manage external FTEs and troubleshoots methods at CROs.
• Initiate investigation of new experimental approaches to a wide range of problems using scientific theory and technical literature.
• QC and analyze data & document all findings & discoveries in an electronic lab notebook in a timely manner.
• Work collaboratively with colleagues in new target biology, chemical biology, informatics, structural biology and medicinal chemistry to advance programs from early hit-finding and help prioritize projects for advancement into lead optimization.
• Collaborate effectively with cross-functional partners within Scorpion to define and develop screening cascades for Scorpion’s novel targets.
• Proactively communicate strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external colleagues.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in Molecular or Cell Biology, Biochemistry or a related field with 5+ years industry experience or 13+ years relevant experience post bachelor’s degree.
• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as, AlphaScreen, TR-FRET, HTRF, ELISA, Nano BRET, FP, etc.
• High technical proficiency in implementing protocols for multi-modal plate readers (e.g., Envision, Neo, Pherastar), liquid handlers (e.g., Multidrop, acoustic dispensers, digital dispensers) & other automated laboratory equipment (e.g., stackers/plate hotels, incubators, etc.).
• Expertise in handling, analyzing and visualizing large data sets coming out of screening assays.
• A strong record of achievement, including contributing to drug discovery programs and publications in high-impact journals.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged self-starter with the desire to work in a fast-paced, multi-tasking environment, with both a collaborative and goal/results-orientated style.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-SP1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated Computational Biologist to join our Data Science team. This role will provide exposure to multiple phases of drug discovery and development, with a mission to leverage information-rich datasets to validate targets, elucidate mechanism of action, and inform patient selection strategy. The successful candidate will interface closely with colleagues across the company, and be a key contributor on a diverse, multidisciplinary team.

KEY RESPONSIBILITIES

• Identify and evaluate novel therapeutic targets through mining large -omics datasets.
• Analyze data from high-throughput molecular assays including RNA-seq, ChIP-seq, ATAC-seq and CRISPR screens.
• Work in close collaboration with scientists from target identification and validation group contributing to experimental design.
• Provide interpretation and analysis of results and present findings in cross-functional project team meetings.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in Computational Biology, Bioinformatics, Statistics, or other quantitative field.
• Strong coding skills, fluency in using R or Python for complex data analysis.
• Experience in analysis of RNA-seq, WES and WGS data.
• Strong understanding of relevant concepts in cancer biology and molecular biology.
• Understanding of current best-practices for high-throughput genomics/molecular data analyses and their underlying statistical principles.
• Experience in network/pathway mapping and integration of orthogonal omics datasets.
• Experience with AWS compute environment is highly preferred.
• Experience with Nextflow DSL is a plus.
• Experience with R-Shiny/data visualization is a plus.
• A strong record of achievement, including publications in high-impact journals.
• Integrity, scientific rigor and commitment to teamwork.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-GK1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated cancer biologist to join our Target Biology team in South San Francisco. The successful candidate will play a key role in target validation and early drug discovery efforts by utilizing cutting edge functional genomic techinques and developing and implementing a variety of biochemical and cell based methods to elucidate target function and enable small molecule screening efforts.

KEY RESPONSIBILITIES

• Evaluate novel precision oncology targets through genetic and pharmacological approaches.
• Design and execute a series of experiments to drive in depth target validation, elucidate mechanistic biology to inform targeting modality, and indentify biomarkers to generate hypotheses for early patient stratification.
• Design, develop, and implement robust biochemical- and cell-based assays to characterize drug/target MOA and measure compound potency and selectivity.
• Collect, analyze, and summarize data for presentations, reports, publications, and patents.
• Keep up to date with the latest scientific advances in technologies and trends in oncology research and development, and contribute to group strategy.
• Mentor and direct junior lab members.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. with a focus on cancer biology, cell or molecular biology, genetics or a closely related area of study.
• 2+ years of industry experience in oncology discovery and a deep knowledge of cancer biology.
• Expertise in genetic perturbation (CRISPR and RNAi) and genetic rescue techniques is required.
• Hands on experience in cell-based assay development and execution across different cellular assay formats (HTFR, BRET, ALPHA screen, ELISA, Protein Simple, western, luminescence, qPCR, etc.).
• A strong record of achievement, including publications in high-impact journals.
• Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• Outstanding decision making, organizational and analytical skills.
• Excellent interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-EJ1

San Francisco, CA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D.and Liron Bar-Peled, Ph.D. Scorpion has secured $270 million in financing since it was founded in the first quarter of 2020 with Series A and B rounds led by Atlas Venture, Omega Funds, Vida Venture, with participation by Abingworth, Partners Health Care, and others.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

Many transcription factors have long been appreciated as important cancer drivers and targets for novel therapies, but have historically been considered “undruggable” using conventional drug discovery approaches. Scorpion Therapeutics is utilizing our fully integrated discovery platform to overcome the challenges of targeting transcription factors.

We are seeking a highly motivated cancer biologist to join our Target Biology team in South San Francisco. The successful candidate will have an in depth knowledge of transcription factor function including mechanisms of regulation, interaction with transcriptional machinery and dynamics of DNA binding. They will play a key role in driving early drug discovery efforts by utilizing cutting edge functional genomic techinques and developing and implementing a variety of biochemical and cell based methods to elucidate target function and enable small molecule screening efforts.

KEY RESPONSIBILITIES

• Design and execute a series of experiments to drive in depth target characterization and elucidate mechanisms of transcription factor regulation using genetic and pharmacological perturbation.
• Provide expertise in transcription factor and cellular biology to early drug discovery programs and contribute to the design of a robust screening funnel to elucidate compound SAR.
• Conceive, develop, and implement robust biochemical- and cell-based assays to characterize drug/target MOA and measure compound potency and selectivity.
• Collect, process, analyze, and summarize data for presentations, reports, publications, and patents.
• Keep up to date with the latest scientific advances in technologies and trends in oncology research and development, and contribute to group strategy.
• Mentor and direct junior lab members.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. with a focus on cancer biology, cell or molecular biology, genetics or a closely related area of study.
• 4+ years of experience in small molecule drug discovery and a deep knowledge of cancer biology.
• Hands-on experience with cell-based, biochemical and biophysical assay techniques typically used to study transcription factor activity and binding interactions (TR-FRET, EMSA, ELISA, ChIP-seq, ATAC-seq, luciferase-reporter, etc).
• Expertise in genetic perturbation (CRISPR and RNAi) and genetic rescue techniques.
• A strong record of achievement, including publications in high-impact journals.
• Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
• Outstanding decision making, organizational and analytical skills.
• Excellent interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-EJ1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, M.D., Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated Computational Biologist with substantial experience in mass spectrometry informatics to join our Data Science team in Boston. The successful candidate will lead methods development for mass-spectrometry based proteome-wide chemical screens data analysis. This role will provide exposure to multiple phases of drug discovery and an opportunity to work with computational chemists, structural biologists and machine learning experts to make a computational drug design a reality.

KEY RESPONSIBILITIES

• Analyze data from high-throughput chemical libraries/proteome interactions screens.
• Build and perfect informatics pipeline for mass spectrometry based proteomics.
• Work in close collaboration with scientists from chemical biology group actively contributing to research, methods development and experimental design.
• Provide interpretation and analysis of results and present findings in cross-functional project team meetings.
• Adhere to reproducible data science best practices.
• Maintain excellent communication across internal and external team members.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in quantitative scientific field and 2+ years of professional experience.
• Experience in development of computational methods for processing and extracting biological data from mass-spectrometry based proteomics datasets.
• Understanding of current state-of-the-art methods for mass-spectrometry based proteomics data analyses and their underlying statistical principles.
• A strong record of achievement, including publications in high-impact journals.
• Strong coding skills, fluency in using Python and/or R for complex data analysis.
• Experience with AWS compute environment is highly preferred.
• Working knowledge of Java is a strong plus.
• Integrity, scientific rigor and commitment to teamwork.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-CT1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, data science, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

This is an exciting opportunity to be part of an evolving Talent Acquisition Team at Scorpion Therapeutics and to be a trusted and visible talent partner to hiring managers. We are looking for a person who is creative, passionate, and proactive about talent discovery and excited about contributing to the development of novel small molecule therapeutics to fight cancer. In this role, you will partner with People & Culture team colleagues, hiring managers, and business leaders to develop and deliver effective talent discovery and engagement strategies to attract top talent. You will manage the end-to-end talent discovery process, including development of all talent discovery strategies, managing candidate engagement and talent pipeline building for critical skill sets across disciplines at Scorpion Therapeutics to meet its near and longer-term strategic hiring objectives.

KEY RESPONSIBILITIES

• Partner with the Principal Talent Partner, hiring managers and leaders across the organization to define roles, measure and communicate progress, improve existing programs and develop innovative sourcing and recruiting strategies.
• Act as a trusted advisor and partner to managers and leaders by proactively gathering market insights and intelligence related to talent and the competitive biopharmaceutical talent landscape.
• Source top biotech talent across all disciplines through multiple channels and build healthy robust pipelines of highest quality candidates on a continuous basis from which we can effectively hire and grow the team.
• Review resumes and interview candidates to determine the appropriateness of skills, experience, and knowledge in relation to position requirements across all different disciplines and all levels.
• Ensure consistent and effective communication approaches regarding discovery efforts by providing status updates to all stakeholders through meetings, email updates, weekly, monthly, and quarterly updates.
• Introduce new and/or improved methodologies for attracting, assessing, and selecting the best talent.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• B.S./B.A. degree required.
• 8-10 years of successful Sourcing, Recruiting, and Executive Search experience in Pharma/Biotech industry (or equivalent transferrable experience).
• Experience sourcing, building talent pipelines, interviewing, negotiations, closing, and overall candidate relationship management.
• Provide excellent support and effective communication to ensure an excellent candidate and hiring manager experience.
• Ability to build strong, productive relationships with hiring managers, leaders and external vendors.
• Experience managing and prioritizing multiple searches, projects, and client relationships and succeeding in a fast-paced dynamic environment.
• Proficient use of Microsoft Suite products, Applicant Tracking Systems, and LinkedIn.
• Team player with a “hands on” approach willing to roll-up your sleeves and get the job done.
• Exceptional organizational skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

APPLY AT CAREERS@SCORPIONTX.COM

#LI-AV1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. Our mission is to deliver the next generation of precision small molecule oncology medicines for patients that do not have effective therapies. We are utililzing our integrated cellular proteomics platform to identify ligandable sites on targets that have previously been considered “undruggable”, and to make best-in-class medicines for drug targets where available medicines are not fully efficacious. To realize this goal, Scorpion has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

We seek an exceptional Scientist who is motivated by this mission and are excited to collaborate within integrated teams of cancer biology, proteomics, computational biology, structural biology, and medicinal chemistry experts. This candidate will serve a critical role in establishing and running cell-based assays to inform target biology and help drive our small molecule drug discovery programs. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES:

• Independently designing and executing experiments to inform target biology using a variety of approaches, including cell line engineering, analysis of signaling pathways, and characterization of cell proliferation and death mechanism(s).
• Developing and executing high throughput cell-based assays.
• Designing and conducting mechanism of action studies on small molecule inhibitors.
• Developing in vitro and in vivo pharmacodynamic readouts for novel oncology targets.
• Genetic manipulation of cells utilizing knockdown or knockout and over-expression of proteins for target validation.
• Using decision making, organizational and communication skills to effectively collaborate with colleagues in biology, chemo-proteomics, and medicinal chemistry.
• Processing, analyzing, documenting, and presenting data, conclusions, and proposed next steps at various venues, including project team, department, and company meetings.

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• BS/MS in Biology or a related field, with oncology experience preferred but not required.
• 5-10 years of relevant laboratory experience.
• A deep and broad understanding of cell culture, assay implementation, and data processing with excellent scientific rigor.
• Broad experience optimizing, running, and analyzing standard cellular assays (CTGlo, BrdU, HTRF, AlphaLISA)
• Proficiency in using a variety of methods to assess protein function (e.g. CRISPR knockouts/knockins, CRISPR rescue, western/co-IP, domain mutagenesis, ChIP and ChiP seq)
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
• Desire to work in a fast-paced, multi-tasking team environment, while employing tact, patience, diplomacy and a collaborative spirit.
• A strong record of achievement, including contributing to drug discovery programs and publications is highly desirable.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
Apply at: CAREERS@SCORPIONTX.COM

LI-RP1

Boston, MA

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D., and Liron Bar-Peled, Ph.D. Our mission is to deliver the next generation small molecule oncology medicines for patients that do not have effective therapies. We are utilizing our integrated cellular proteomics platform to identify ligandable sites on targets that have previously been considered “undruggable”, and to make best-in-class medicines for drug targets where available medicines are not fully efficacious. To realize this goal, Scorpion has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion’s mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We seek an exceptional Senior Scientist who is motivated by this mission and are excited to collaborate within integrated teams of cancer biology, proteomics, computational biology, structural biology, and medicinal chemistry experts. The successful candidate will have a proven ability to design, develop and execute genetic and cellular assays that validate and characterize target protein function. They will play a key role in driving early drug discovery efforts by utilizing cutting edge functional genomic techniques and developing and implementing a variety of biochemical and cell-based methods to elucidate target function and enable small molecule screening efforts. They will also grow in their ability to lead projects and mentor others. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

KEY RESPONSIBILITIES

• Design and execute a series of experiments to validate and characterize target protein function
• Organization, scale-up, execution, and analysis of cellular assays that assesses drug potency and selectivity
• Provide expertise in cellular, genetic, and/or protein biology to early drug discovery programs and contribute to the design of a robust screening funnel to elucidate compound activity
• Work cross-functionally within a drug discovery team comprised of different expertise (biochemistry/biophysics, chemical biology, pharmacology, chemistry, etc.)
• Collect, process, analyze, and summarize data for presentations, reports, publications, and patents
• Keep up to date with the latest scientific advances in technologies and trends in oncology research and development, and contribute to group strategy
• Mentor and direct junior lab members
• Maintain excellent communication across internal and external team members

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. with a focus on cancer biology, cell or molecular biology, genetics or a closely related area of study, or MS with extensive drug discovery experience in an industry setting
• 5+ (PhD) or 10+ (MS) years of experience in small molecule drug discovery and a deep knowledge of cancer biology
• Hands-on experience with assay techniques typically used to study protein regulation in cells (TR-FRET, EMSA, ELISA, co-immunoprecipitation, reporter assays, proteomic techniques, etc.)
• Expertise in genetic perturbation (CRISPR and RNAi) and genetic rescue techniques
• A strong record of achievement, including publications in high-impact journals
• Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution
• A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style
• Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit
• Outstanding decision making, organizational and analytical skills
• Excellent interpersonal and communication skills

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
Apply at: CAREERS@SCORPIONTX.COM

LI-RP1

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion’s mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly motivated accomplished leader to join our company in our Boston, MA office. This candidate will serve a critical role, responsible for setting and leading the global regulatory strategy and designing and managing all GxP programs and staff to ensure compliance with global laws, regulations and applicable guidance. He/she will be responsible for supporting the Company growth and infrastructure as the portfolio expands.

KEY RESPONSIBILITIES

• Oversee global regulatory strategy and global regulatory submissions (eg, INDs, CTAs, NDAs, MAAs, meeting requests, and briefing documents) in compliance with all applicable global regulatory requirements and alignment with corporate goals
• Collaborate with research, non-clinical development, CMC and clinical development to develop regulatory strategies which will maximize the value of our assets
• Serve as the primary company contact to the FDA and other competent authorities; Foster a strong relationship, partnership, and advocacy with global regulatory authorities
• Proactively identify regulatory risks to company’s programs and develop risk mitigation plans
• Serve as the company subject matter expert on regulatory trends and guidance’s and keeps company apprised of expected changes to the regulatory landscape affecting existing and future regulatory policies, regulations, and standards
• Provide training, and interpretation of regulatory guidelines or issues to personnel
• Develop and manage Global Regulatory Affairs and QA budgets
• Develop, implement, maintain, and communicate the Company’s quality strategy and programs
• Provide leadership and strategic guidance in ensuring continuous compliance with all applicable internal and external regulations, standards, policies, and procedures related to the quality, regulatory status, and performance of Company operations, processes, and products
• Design and maintain a fit-for-purpose quality management system (QMS) across the GxPs
• Ensure the qualification, selection and management of vendors and contractors through a defined qualified process
• Create and execute a plan for ensuring a state of inspection readiness and continuous improvement
• Create a process for identifying, adjudicating and remediating risks and/or compliance concerns/issues. Ensure rapid escalation of significant quality issues or concerns
• Develop fit-for-purpose company SOPs, work instructions, and other processes and ensure appropriate training and adherence.
• Ensure that company and departmental SOPs, job descriptions, and training documentation are current, relevant, and appropriately maintained

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Minimum of 15 years of biotech/biopharmaceutical leadership, with a demonstrated record of drug development within the life sciences industry
• M.S./PhD/PharmD preferred
• Demonstrated leadership to design and build a Regulatory and Quality organization needed to achieve company objectives
• Broad and deep regulatory agency knowledge and experience interpreting and guiding application of global regulatory requirements across multiple GxPs; Extensive exposure with multiple regulatory agencies
• Extensive experience leading, designing, writing and submission of regulatory filings and correspondence
• Ability to build and maintain effective internal and external relationships, including with cross-functional teams, individual contractors, contract research organizations, and other vendors to effectively manage all regulatory and quality related activities
• Proven ability to dissect complex issues to quickly distill key issues for discussion with regulatory authorities and guide teams (internally/externally) in the preparation of responses to regulatory questions
• Demonstrated and extensive hands-on experience in the preparation, review, and finalization of GxP policies, procedures, SOPs, trainings, and corrective actions for both early and late development programs
• Demonstrated success leading within a high growth, innovative, and rapidly changing environment
• Team builder who leads by example, employs expertise and influence to encourage collaboration across departments, levels, and groups to achieve key corporate objectives
• Excellent written and oral communication skills and the ability to effectively communicate with internal and external team members on project activities
• Strong problem solving, critical thinking and analytical skills, required to make sound decisions
• Great attention to detail; ability to organize, prioritize, delegate and adapt quickly to changing environments and priorities

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation. Apply at: CAREERS@SCORPIONTX.COM

LI-KS1